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FLASH GENE
Symbol CCT6A contributors: mct/npt/pgu - updated : 27-03-2013
HGNC name chaperonin containing TCP1, subunit 6A (zeta 1)
HGNC id 1620
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
ATP-binding sites perfectly conserved among mammals and yeast
mono polymer heteromer
HOMOLOGY
interspecies homolog to yeast S.cerevisiae
Homologene
FAMILY
  • TCP-1 chaperonin family
  • TF55/TCP-1 family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • mediating ATP-dependent monomeric protein folding
  • molecular chaperone that assists the folding of proteins upon ATP hydrolysis
  • required for maturation of sphingosine kinase 1
  • CCT complex is responsible for the folding of a number of proteins including actin and tubulin
  • might play an essential role in modulation of folding of polyglutamine expanded proteins and could be another target for further therapeutic studies
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a heterooligomeric complex, subunits of the CCT complex involved in ATP-dependent folding of cellular proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with androgen receptor (AR)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS