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FLASH GENE
Symbol PCDHA8 contributors: npt - updated : 09/10/2008
HGNC name protocadherin alpha 8
HGNC id 8674
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • six extracellular cadherin repeats
  • a transmembrane segment encoded by a unique exon
  • a cytoplasmic tail identical for each protein in the cluster
  • two PXXP motifs
  • a putative SH3 protein-binding site
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus norvegicus Pcdha8 protocadherin alpha 8
    intraspecies homolog to cadherin
    Homologene
    FAMILY
  • cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
  • protocadherin family
  • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text integral membrane protein type 1, localized at the synaptic junction
    basic FUNCTION
  • cadherin-related neuronal receptor, putatively involved in the specificity of neuronal connections
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    text playing a putative role in cell-cell interaction critical in the development of the central nervous system, mediating adhesion in synaptic junctions through lack-in process
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein cytoplasmic domain putatively connecting to intermediate filaments
    cell & other
  • cells expressing the same protocadherin
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS