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FLASH GENE
Symbol SLC7A6 contributors: mct - updated : 27-06-2011
HGNC name solute carrier family 7 (cationic amino acid transporter, y+ system), member 6
HGNC id 11064
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve transmembrane segments
  • cytoplasmic N and C termini
  • two conserved cysteine residues between TM3 and TM4
  • the first residue interacting with a cysteine in the 4F2 heavy chain
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • solute carrier family 7, cationic amino-acid
  • k1 glycoprotein associated aminoacid transporter family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • high-affinity permease for methionine
  • potentially a major contribution to the transport of cationic amino acids in pachytene spermatocytes and early spermatids
  • Na+-independent neutral l-amino acid transporter, that may may play a crucial role in the development and maintenance of podocyte structure and function by regulating protein synthesis and the actin cytoskeleton
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    PATHWAY
    metabolism aminoacid
    signaling
    a component
  • heterodimerizing with the cell surface glycoprotein to form a complex mediating y+L -type transporter exchanging cationic aminoacids and/or neutral aminoacids together with sodium
  • system-L (SLC7A5, SLC7A8, SLC7A7, SLC7A6), which is the major transporter of tyrosine
  • INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with SLC7A7
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS