SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
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| intracellular,nucleus,chromatin/chromosome,nucleosome
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| intracellular,nucleus,nucleolus
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basic FUNCTION
| implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly |
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acting as an RNA helicase |
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may be an alternative splicing regulatory factor |
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is required for optimal function of the zinc-finger antiviral protein. |
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DDX5 and DDX17 have been shown to act as transcriptional |
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co-activators for a diverse range of transcription factors, including oestrogen receptor-alpha (ESR1) |
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crucial role for DDX17 in ESR1 co-activation and oestrogen-dependent cell growth and likely distinct but important roles for both DDX5 and DDX17 in regulating ESR1 activity in breast cancer |
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critical role for DDX5 and DDX17 in tumor cell migration through the fine regulation of NFAT5 pathway |
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DDX5 and DDX17 are members of a large family of highly conserved proteins that are involved in gene-expression regulation |
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RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation |
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has dual roles in the recognition of stem loops: in the nucleus for endogenous microRNA (miRNA) biogenesis and in the cytoplasm for surveillance against structured non-self-elements |
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DDX17 is a SOX2-binding protein in ER-positive breast cancer |