motifs/domains
| bipartite nuclear localization signal (NLS) |
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a glucose-sensing module (GSM) that mediates glucose responsiveness |
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a low-glucose inhibitory domain (LID) |
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a glucose-response activation conserved element (GRACE) |
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two NES sequences, NES2 and now the new NES1 coordinate to interact together with CRM1 (exportin) for nuclear export of the carbohydrate response element binding protein ) |
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a DNA binding helix-loop-helix/leucine zipper (bHLH/ZIP) domain at the C terminal region (AAs 600–860), and proline-rich regions |
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C-terminal 227 AA region containing the DNA-binding domain interacted with FLII |
SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,lumen
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| intracellular,cytoplasm,cytosolic
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,chromatin/chromosome
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text
| shuttles between the cytoplasm and nucleus |
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translocated into the nucleus in response to high glucose levels, and then up-regulates transcriptional activity |
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sequestered in the cytosol at low glucose concentrations, but upon stimulation with glucose and activation of Ca(2)(+) influx, rapidly translocates to the nucleus |
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ketone bodies play an important role in the regulation of MLXIPL activity by restricting MLXIPL localization to the cytoplasm, thus inhibiting fat synthesis during periods of ketosis |
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MLXIPL and FLII localized in both the cytoplasm and nucleus of cancer cells |
basic FUNCTION
| helix-loop-helix/leucine zipper (bHLH/ZIP) transcription factor that binds to carbohydrate response element in the promoter of some glucose-regulated genes and activates their expression upon glucose stimulation |
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regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein |
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coordinates transcriptional regulation of enzymes that channel glycolytic end-products into lipogenesis and energy storage |
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transcription factor that mediates glucose-responsive changes in gene expression in hepatocytes |
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in the liver, is responsible for converting excess carbohydrate to fatty acids for long-term storage |
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plays a key role both in redirecting glucose metabolism to anabolic pathways and suppressing TP53 activity |
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activates a number of glycolytic and lipogenic genes in response to glucose stimulation |
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responsible for conversion of dietary carbohydrate to storage fat in liver by coordinating expression of the enzymes that channel glycolytic pyruvate into lipogenesis |
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transcription factor whose expression and activity are increased in pancreatic beta-cells maintained at elevated glucose concentrations ( |
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glucose-responsive transcription factor required for fatty acid synthesis in the fed state |
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important transcription factor in the pathogenesis of obesity and diabetes and their complications ( |
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identified as a transcription factor regulating the induction of liver pyruvate kinase and other lipogenic genes in response to a high carbohydrate diet and it contribute potentially to the glucose-responsiveness of PNPLA3 |
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functions as a transcription factor in mediating the glucose-activated gene expression of multiple liver enzymes, which are responsible for converting excess carbohydrate to storage fat |
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required for maximal induction of RGS16 during fasting, suggesting that RGS16 couples hepatic glucose production with the rate of fatty acid oxidation |
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function in managing the utilization of fatty acids during prolonged fasting, by inducing expression of FGF21 to promote fat mobilization from WAT stores and RGS16 to couple gluconeogenesis to the modulation of fatty acid oxidation in hepatocytes |
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emerging as an important mediator of glucotoxity both in the liver and in the pancreatic beta-cells |
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major determinant of adipose tissue fatty acid synthesis and systemic insulin sensitivity |
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adipose tissue MLXIPL has a key role in integrating adipocyte and whole-body metabolic function and this may be mediated by transcriptional regulation of the potent CHREBP-beta isoform |
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glucose-responsive transcription factor that plays a critical role in converting excess carbohydrate to storage fat in liver |
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FLII is a component of the MLXIPL transcriptional complex and negatively regulates MLXIPL function in cancer cells |
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SREBF1 and MLXIPL are major transcriptional regulators that induce key lipogenic enzymes to promote lipogenesis in the liver |
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plays a key role in the dietary fructose transport as well as conversion into lactate and glucose through direct transcriptional control of genes involved in fructose transport, fructolysis, and gluconeogenesis |
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