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FLASH GENE
Symbol AKT3 contributors: mct - updated : 29-11-2014
HGNC name v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
HGNC id 393
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a SH2 and a pleckstrin (PH) homology N terminal domain
  • a short alpha helical linker
  • a C terminal kinase domain
  • HOMOLOGY
    interspecies homolog to V-akt murine thymoma viral oncogene 3
    homolog to C.elegans F28H6.1
    Homologene
    FAMILY
  • Ser/Thr protein kinase, B family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    intracellular,nuclear envelope
    text
  • localized in both the nucleus and nuclear membrane
  • basic FUNCTION
  • AKT is a key regulator for cell growth, cell survival and metabolic insulin action
  • involved in the regulation of diverse cellular functions such as cell proliferation, energy metabolism, and apoptosis
  • AKT2 and AKT3 play an important role in the viability of human malignant glioma cells
  • may oppose AKT1 in lung tumorigenesis and lung tumor progression
  • AKT1 and AKT3 are essential for the proliferation of reprogrammed cells
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    text survival of lymphoid and other cell types
    PATHWAY
    metabolism
    signaling
  • central role of PI3K/AKT signaling in vascular, limb and brain development
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • enhanced AKT2 or AKT3 activation also promotes reprogramming and coordinates with LIF to activate STAT3
  • AKT3 is likely a regulator of mitochondrial dynamics in the vasculature via regulation of XPO1-dependent nuclear export
  • cell & other
    REGULATION
    activated by growth factors via PI3K (phosphatidyl inositol 3-kinase) binding to PH domain in the antiapoptotic PI3K pathway induced by insulin growth factor 1, and maybe other
    coactivated by TCL1
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL1Q44 , MPPH2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in estrogen receptor-negative breast tumor
    tumoral       gain of function
    associated with the survival of melanoma cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene for microcephaly and corpus callosum agenesis in 1qter microdeletion syndrome
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    targeting AKT2 and AKT3 may hold promise for the treatment of patients with gliomas (PMID: 20167810)
    ANIMAL & CELL MODELS