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FLASH GENE
Symbol NCBP2 contributors: mct - updated : 29-01-2013
HGNC name nuclear cap binding protein subunit 2, 20kDa
HGNC id 7659
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one RNA recognition motif
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Ncbp2
    Homologene
    FAMILY
  • RRM NCBP2 family
  • CATEGORY RNA associated , transcription factor , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in mediating u snRNA export from the nucleus. binds to 5'capped mRNA
  • CELLULAR PROCESS nucleotide, transcription, maturation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the cap-binding protein complex in association with NCBP2 and other proteins, mediating premRNA splicing and export of U small nuclear RNAs to the cytoplasm
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NCBP1, NCBP2 independently interact with EIF4GI
  • NCBP1/NCBP2 initially undergo a pioneer round of translation (EIF4G1 potentially serves to connect NCBP1/NCBP2 with other initiation factors during the pioneer round of translation)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS