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FLASH GENE
Symbol SEC24C contributors: mct/npt - updated : 19-12-2011
HGNC name SEC24 related gene family, member C (S. cerevisiae)
HGNC id 10705
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to yeast S.cerevisiae Sec24p
Homologene
FAMILY
  • SEC23/SEC24 family
  • SEC24 subfamily
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    text associated with COPII structures on membranes of the ER-Golgi boundary
    basic FUNCTION
  • vesicle biogenesis from endoplasmic reticulum
  • role in selective export of membrane proteins from the endoplasmic reticulum
  • required for docking the prechylomicron transport vesicle with the Golgi
  • variations in the SEC24C gene may also affect SLC6A4 cell surface levels and thus be linked to mood disorders
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SEC13, SEH1L
  • interacting with SLC6A4 (SLC6A4 can only exit the ER by recruiting SEC24C)
  • a triple arg motif mediates ADRA2B interaction with SEC24C/D and export from the endoplasmic reticulum (ER)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS