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FLASH GENE
Symbol DGKB contributors: mct/npt - updated : 30-05-2018
HGNC name diacylglycerol kinase, beta 90kDa
HGNC id 2850
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N terminal EF hand calcium-binding domains
  • two phorbol esters/diacylglycerol binding domain (C1 domain)
  • a DAG catalytic domain
  • a DAG accessory domain
  • cysteine-rich zinc finger like (? LIM domain) and putative ATP-binding sites
  • HOMOLOGY
    interspecies homolog to rattus diacylglycerol
    Homologene
    FAMILY
  • eukaryotic diacetylglycerol kinase family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text one variant to cytoplasm, the other to plasma membrane
    basic FUNCTION
  • key enzymes in lipid metabolism that function to reintroduce diacylglycerol formed from the hydrolysis of phospholipids into the biosynthetic pathway
  • invoved in phosphorylation of long chain diacetylglycerols
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • Ca2+
  • ATP
  • protein
    cell & other
    REGULATION
    activated by stimulated phosphatidylserine
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in Wilms tumor
    Susceptibility to decreased glucose-stimulated insulin response
    Variant & Polymorphism other
  • variants at the DGKB/AGMO, ADRA2A, GLIS3 and C2CD4B loci were associated with decreased glucose-stimulated insulin response
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS