basic FUNCTION
| may be involved in protein transport, small GTPase mediated signal transduction |
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significantly influencing cell-cycle, apoptosis, cytoskeleton and membrane-trafficking pathways |
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playing a physiological role in mitosis and apoptosis by recruiting regulatory proteins to the Cul3 complex to be targeted for degradation |
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tumor suppressors that might function as adaptors of CUL3-dependent ubiquitin ligase complexes |
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play a part in the carcinogenic process through a mechanism that involves the decreased or abolished expression of the corresponding genes, or more rarely, mutations that result in impaired functioning of the protein, presumably leading to the accumulation of RhoBTB substrates and alterations of the cellular homeostasis |
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important tumor suppressor gene related with breast cancer and may play antitumor roles by inhibiting proliferation, preventing colony formation and promoting the apoptosis of tumor cells |
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RHOBTB2 protein participated in various cellular activities and influenced pathways responsible for cell cycle and apoptosis |
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similar to other atypical Rho GTPases, RHOBTB2 was found to have retained the capacity to bind GTP, modulated by the HSP90AA1 ATPase cycle |
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functions as a multifunctional tumor suppressor in thyroid cancer cells via mitochondrial apoptotic pathway |
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suppresses tumorigenesis in breast cancer by ubiquitinating MSI2 |