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FLASH GENE
Symbol GABPB1 contributors: mct - updated : 02-06-2015
HGNC name GA binding protein transcription factor, beta subunit 1
HGNC id 4074
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four tandemly repeated NOTCH motifs at the C terminus
  • a C terminus ETS DNA-binding domain
  • five ankyrin (ANK) repeats
  • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to rattus Gabpb1 (98.6 pc)
    homolog to murine Gabpb1 (98.2 pc)
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • putatively involved in the activation of nuclear genes specifying mitochondrial function
  • being necessary for the expression of the Adenovirus E4 gene
  • GABPB1, GABPB2, GAPBA controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component with GABPA alpha2/beta2 of an heterotetramer nuclear respiratory factor 2
  • INTERACTION
    DNA interacting with purine rich repeats (GA repeats)
    RNA
    small molecule
    protein
  • GABPA
  • NRF2 (E4F1) regulating STK6
  • recognizing an important site for herpes virus type I activation
  • interacting with HCFC1, causing repression of transcriptional activity
  • binding to GAPBA (through a DNA binding domain that binds to N-terminal ankyrin-like repeats of GABPB1 and GABPB2)
  • PRKD2 is a functionally significant mediator of the effect of GABPA, GABPB1, GABPB2 on proliferation and apoptosis of BCR-ABL–expressing cells
  • SIRT7 is a dynamic nuclear regulator of mitochondrial function through its impact on GABPB1 function
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS