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FLASH GENE
Symbol HOMER3 contributors: KTN/npt - updated : 29-08-2007
HGNC name homer homolog 3 (Drosophila)
HGNC id 17514
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PDZ (PSD95/disc large/ZO-1) domains
  • a WAS homology domain (WH1)
  • a variant EVASP and a C terminal coiled-coil region
  • mediating self-multimerization
  • mono polymer homomer , heteromer , oligo
    HOMOLOGY
    interspecies homolog to chimpanzee HOMER3 (99.45 pc)
    homolog to rattus Homer3 (91.06 pc)
    homolog to murine Homer3 (90.17 pc)
    homolog to chicken HOMER3 (72.29 pc)
    Homologene
    FAMILY
  • Homer family of cytoplasmic scaffolding proteins
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text postsynaptic density
    basic FUNCTION
  • clustering and linking metabotropic glutamate receptors group I with the inositol triphosphate receptors regulator of GRMs signaling
  • being a negative regulator of T cell activation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HOMER1
  • FAT
  • interacting with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS