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FLASH GENE
Symbol GRM1 contributors: mct - updated : 17-10-2017
HGNC name glutamate receptor, metabotropic 1
HGNC id 4593
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • C-terminal PDZ-binding motif
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text
  • recruitment to lipid rafts is enhanced by agonist binding and is supported at least in part by an intact cholesterol recognition/interaction amino acid consensus (CRAC) motif in the receptor
  • basic FUNCTION
  • activating PI turnover and triggering intracellular calcium release
  • important neuronal mediator of postsynaptic signaling that influence synaptic strength, plasticity, and other factors
  • control metaplasticity of spinal learning through a PKC-dependent mechanism
  • with GRM5, plays a role in the early stages of corticogenesis with, however, a different contribution to human cortical developmental events
  • involved in synaptic activities, learning and neuroprotection
  • important role of GRM1 in pain-related amygdala plasticity and evidence for the involvement of HOMER1 proteins in the forebrain in the modulation of pain hypersensitivity
  • plays an important role in cerebellar development and synaptic plasticity
  • can be an oncogene in epithelial cells
  • GRM1, GRM5 play critical functions in forms of activity-dependent synaptic plasticity and synapse remodeling in physiological and pathological states
  • assembly of two covalently linked monomers into dimeric complexes is a prerequisite for metabotropic glutamate receptor 1 (GRM1) function
  • plays an important role in synaptic plasticity and cerebellar development
  • GRM1, GRM5 are key elements in the dynamic regulation of cholinergic synaptic inputs onto neurons of the thalamic reticular nucleus (TRN)
  • novel function of ubiquitination in the regulation of GRM1, as well as its role in mGluR-dependent AMPAR endocytosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of phosphate receptors
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to homer proteins
  • activating FMR1, TRPC1 and DLG4(activation GRM1-dependent)
  • binding partner of GOPC, through its PSD95/discslarge/ZO1 homology domain (inhibit GRM1-mediated ERK1/2 activation, without an apparent effect, via the C-terminal-truncated receptor)
  • molecular link between GRM1 and FMR1 in the anterior cingulate cortex (ACC), a key region involved in high brain cognitive and executive functions
  • associates with the PDZ protein tamalin (GRASP)
  • interaction with caveolin-1 which controls the rate of constitutive GRM1 internalization
  • in addition to the MAPK pathway previously reported being a downstream target of stimulated GRM1, AKT2 is another downstream target in GRM1 mediated melanocyte transformation
  • STIM1 controls neuronal Ca++ signaling, GRM1-dependent synaptic transmission, and cerebellar motor behavior
  • cooperative signaling between GRM1 and GRM5 is in a manner inconsistent with heterodimerization, and thus suggest an interaction between homodimers
  • NRG1 selectively increases GRM1-activated currents by inducing synthesis and trafficking to membrane of functional receptors
  • cell & other
  • linked to inositol phosphate receptors
  • REGULATION
    Other regulation of its localization and function by Homer proteins
    ASSOCIATED DISORDERS
    corresponding disease(s) SCAR13 , SCA44
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrantly expressed in melanomas
    tumoral       gain of function
    through gene fusion and promoter swapping in chondromyxoid fibroma
    Susceptibility to melanoma
    Variant & Polymorphism other increasing the risk of GRM1
    Candidate gene
    Marker
    Therapy target
  • potential therapeutic target for promoting use-dependent plasticity after spinal cord injury
  • ANIMAL & CELL MODELS