basic FUNCTION
| involved in RNA localization in polarized neurons |
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involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles |
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important role in the formation and maintenance of dendritic spines of hippocampal neurons |
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dendritic mRNA transport is mediated potentially via the STAU2 and kinesin motor proteins and might be modulated by the neuronal activity and mitogen-activated protein kinase pathway |
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could be involved in double-stranded RNA binding events |
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transport dendritic mRNAs along microtubules |
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potential role for STAU2 in the generation and regulation of MAP1B mRNA containing granules that are required for GRM-dependent long-term depression |
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implicated in mRNA transport and dendritic spine morphogenesis |
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recruitment of STAU2 alone or in combination with UPF1 differentially affects the fate of mRNAs |
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double-stranded mRNA binding protein known to regulate dendrite formation as well as cell survival and migration |
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translation control of specific STAU2-associated transcripts may be a key regulator of tissue size |
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regulates eye size during development and all STAU2 isoforms expressed in the neuropethelial tissue share this important ability |
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functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity |
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implicated in both dendritic RNA localization and synaptic plasticity in mammalian neurons |
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is likely an anti-apoptotic protein that could be involved in DNA replication and/or maintenance of genome integrity and its expression is regulated by E2F1 via the ATR signaling pathway |
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double-stranded RNA-binding protein involved in cell fate decision by regulating mRNA transport, mRNA stability, translation, and ribonucleoprotein assembly |
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is likely required for spindle formation and timely meiotic progression in oocytes |
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RNA-binding protein involved in the post-transcriptional regulation of gene expression |
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critical contribution of STAU2 to various forms of synaptic plasticity including spatial working memory and cognitive management of new environmental information |