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FLASH GENE
Symbol STAU2 contributors: mct/npt - updated : 08-12-2014
HGNC name staufen, RNA binding protein, homolog 2 (Drosophila)
HGNC id 11371
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three double-stranded RNA-binding (ds RBD) domains, (the third double-stranded RNA-binding domain (RBD3)is essential for RNA interaction)
  • HOMOLOGY
    interspecies homolog to Drosophila Staufen,2
    Homologene
    FAMILY
  • double-stranded RNA (dsRNA)-binding proteins family
  • CATEGORY regulatory , RNA associated , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,nucleolus
    text nuclear import is dependent on a nuclear localization signal in close proximity to the RBD3, the nuclear export is not dependent on CRM1 but rather on XPO5
    basic FUNCTION
  • involved in RNA localization in polarized neurons
  • involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles
  • important role in the formation and maintenance of dendritic spines of hippocampal neurons
  • dendritic mRNA transport is mediated potentially via the STAU2 and kinesin motor proteins and might be modulated by the neuronal activity and mitogen-activated protein kinase pathway
  • could be involved in double-stranded RNA binding events
  • transport dendritic mRNAs along microtubules
  • potential role for STAU2 in the generation and regulation of MAP1B mRNA containing granules that are required for GRM-dependent long-term depression
  • implicated in mRNA transport and dendritic spine morphogenesis
  • recruitment of STAU2 alone or in combination with UPF1 differentially affects the fate of mRNAs
  • double-stranded mRNA binding protein known to regulate dendrite formation as well as cell survival and migration
  • translation control of specific STAU2-associated transcripts may be a key regulator of tissue size
  • regulates eye size during development and all STAU2 isoforms expressed in the neuropethelial tissue share this important ability
  • functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity
  • implicated in both dendritic RNA localization and synaptic plasticity in mammalian neurons
  • is likely an anti-apoptotic protein that could be involved in DNA replication and/or maintenance of genome integrity and its expression is regulated by E2F1 via the ATR signaling pathway
  • double-stranded RNA-binding protein involved in cell fate decision by regulating mRNA transport, mRNA stability, translation, and ribonucleoprotein assembly
  • is likely required for spindle formation and timely meiotic progression in oocytes
  • RNA-binding protein involved in the post-transcriptional regulation of gene expression
  • critical contribution of STAU2 to various forms of synaptic plasticity including spatial working memory and cognitive management of new environmental information
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • components of RNPs that travel along microtubules from the soma to distant dendritic sites
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • interacting with XPO5, through the RBD3 in an RNA-dependent manner
  • interaction of STAU2 with the Y14-MAGOHB heterodimer seems to represent a highly conserved complex as the same proteins are involved in the STAU2-mediated localization of Oskar mRNA in Drosophila oocytes
  • ZFR, a three zinc finger protein, was identified as an interacting protein of STAU2
  • MAPK pathway could modulate dendritic mRNA transport through its interaction with STAU2
  • PABPC1L and YBX1 associate with STAU2-containing mRNPs through RNAs
  • RUFY3 binding with STAU2
  • involved in the regulation of two important genes that regulate eye size, SOX2, HES1
  • double-stranded RNA-binding protein that interacts directly with UPF1 to reduce the half-life of STAU1-mediated mRNA decay targets that form an STAU1-binding site by either intramolecular or intermolecular base-pairing
  • cell & other
    REGULATION
    Phosphorylated by CDK1 (STAU2 isoforms are phosphorylated during mitosis and the phosphorylation process involves CDK1)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS