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FLASH GENE
Symbol ATP2C1 contributors: mct - updated : 20-11-2018
HGNC name ATPase, Ca++ transporting, type 2C, member 1
HGNC id 13211
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to yeast calcium pump Pmr1
intraspecies homolog to ATP2C2 (64 p100)
Homologene
FAMILY
  • P-type cation transport ATPases family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • mostly excluded from the cores of the Golgi cisternae and is instead located mainly on the lateral rims of Golgi stacks, in tubular noncompact zones that interconnect different Golgi stacks, and within tubular parts of the trans Golgi network
  • basic FUNCTION
  • sequestering calcium into the Golgi in yeast
  • catalyzing the hydrolysis of ATP coupled with the transport of the calcium
  • playing an important role in homeostatic maintenance throughout the secretory pathway
  • in the Golgi apparatus where it is actively involved in the transport of Ca(2+) or Mn(2+) from the cytosol to the Golgi lumen
  • importance of its function for normal neural differentiation
  • important role in Golgi homeostasis of Ca(2+)
  • in spermatozoa, appears to play a major role in the regulation of cytosolic calcium transients
  • correct SPCA1 functioning is crucial to intra-Golgi transport and maintenance of the Golgi ribbon
  • have important roles in the mammary gland and likely contribute to the secretion of calcium into milk
  • key regulator of IGF1R processing in basal breast cancer cells
  • P-type pump that transports Mn(2+) from the cytosol into the Golgi
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CFL1 is required for actin and P-type ATPase secretory pathway calcium ATPase (ATP2C1)-dependent sorting of secretory proteins at the trans-Golgi network (TGN)
  • TMEM165 expression is linked to the function of ATP2C1
  • the function of ATP2C1 is linked to the stability of TMEM165 in a pathological context of Hailey-Hailey disease
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BCPM
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional somatic mutation LOH    
    loss of allele in more severely affected segmental skin regions of chronic pemphigus
    constitutional       loss of function
    renders cells hypersensitive to ER stress
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    ATP2C1 modulation and regulation of Golgi calcium transport may provide a unique opportunity for therapeutic targeting of this important pathway in breast cancer
    ANIMAL & CELL MODELS