| basic FUNCTION
| interacting signal transduction events that induce inflammatory and proliferative responses to TNF stimulation |
|
regulator of ceramide production |
|
TNFRSF1A (TNF-R55)-associated protein essential |
|
for the activation of neutral sphingomyelinase |
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mediates activation of SMPD2 as well as regulation of lysosome size by signaling pathways that operate independent from activation/membrane recruitment of PKC (Möhlig 2007) |
|
involved in TNF-induced gene expression and leukocyte recruitment, contributing to the establishment of the specific immune response (Montfort 2009) |
|
necessary intracellular intermediate for sickness behavior (Palin 2009) |
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recruits the WD repeat protein RACK1 to TNFRSF1A and in complex modulates the activity of SMPD3 (Philipp 2010) |
