basic FUNCTION
| playing an antiproliferative role in the lymphocyte differentiation |
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playing a role in the control of T cell death by regulating the expression of BCL2 |
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novel role for POU2AF1 anf IKZF3 in controlling the transcription and nuclear organization of genes involved in pre-BCR function |
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plays a crucial role in the control of lymphocyte differentiation and proliferation |
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Ikaros family members are critical for a functional immune system that confers protection against invading pathogens, while minimising the risk of leukaemic transformation, immune pathology, and autoimmunity |
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plays an important role in the control of mature B lymphocyte differentiation and maturation |
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involved in cell survival by regulating the expression of some BCL2 family members |
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promotes TH17 differentiation by directly silencing IL2 expression |