Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol IKZF3 contributors: mct - updated : 19-11-2015
HGNC name IKAROS family zinc finger 3 (Aiolos)
HGNC id 13178
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four N terminal C2H2-type zinc fingers comprising the DNA binding domain
  • two C terminal C2H2-type zinc fingers mediating protein dimerization
  • conjugated PhosphoP , MetalloP
    HOMOLOGY
    interspecies homolog to murine Zfpn1a3 (87 pc)
    homolog to rattus Zfpn1a3 (87.9 pc)
    intraspecies homolog to Ikaros,Aiolos
    Homologene
    FAMILY
  • IKAROS family of C2H2-type zinc-finger proteins
  • zinc finger protein, subfamily 1A
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • playing an antiproliferative role in the lymphocyte differentiation
  • playing a role in the control of T cell death by regulating the expression of BCL2
  • novel role for POU2AF1 anf IKZF3 in controlling the transcription and nuclear organization of genes involved in pre-BCR function
  • plays a crucial role in the control of lymphocyte differentiation and proliferation
  • Ikaros family members are critical for a functional immune system that confers protection against invading pathogens, while minimising the risk of leukaemic transformation, immune pathology, and autoimmunity
  • plays an important role in the control of mature B lymphocyte differentiation and maturation
  • involved in cell survival by regulating the expression of some BCL2 family members
  • promotes TH17 differentiation by directly silencing IL2 expression
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text mesoderm development
    PATHWAY
    metabolism
    signaling
    a component
  • homo or heterodimerizing with either other member of the family
  • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • IKZF4
  • IKZF5
  • IKZF3 and IKZF1 bind to the MYC promoter and directly suppress MYC expression in pre-B cells
  • downregulation of MYC by IKZF1 and IKZF3 is necessary for the induction of CDKN1B and downregulation of CCND3
  • STAT3 and the Ikaros zinc finger transcription factors IKZF3, IKZF1 cooperate to regulate BCL66 expression
  • cell & other
    REGULATION
    Other transcription factors Ikaros and NFKB involved in the control of Aiolos expression
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in acute lymphoblastic leukaemia
    tumoral     --over  
    in B-Chronic lymphocytic leukemia
    Susceptibility to systemic lupus erythematosus
    Variant & Polymorphism SNP
  • rs8076347, rs9913957, rs8079075, associated to systemic lupus erythematosus
  • Candidate gene
    Marker
  • IKZF3 deregulation by epigenetic modifications may be a hallmark of Chronic lymphocytic leukemia
  • Therapy target
    ANIMAL & CELL MODELS