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FLASH GENE
Symbol GADD45G contributors: mct - updated : 03-04-2019
HGNC name growth arrest and DNA-damage-inducible, gamma
HGNC id 4097
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY ribosomal protein L7AE/gadd45 family
CATEGORY signaling growth factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION
  • involved in negative control of cell growth,DNA repair and/or apoptosis
  • activating MEKK4 and the p38/JNK pathway in response to environmental stress
  • specific role for GADD45G in male fertility and testis development
  • regulates the thermogenic capacity of brown adipose tissue
  • GADD45 family proteins play a crucial role in regulating cellular stress responses and apoptosis
  • plays a critical role in metastasis of prostate and breast cancer cells (PMID
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text negative control of cell growth noteworthy the pituitary cell proliferation
    PATHWAY
    metabolism
    signaling
  • potential signaling cascade, involving GADD45G &
  • 8594; MAPK14 &
    8594; GATA4 &
    8594; SRY, regulating male sex determination
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • mediating activation of stress responsive MEKK4,MAPKKK (MAP3Kx)
  • GADD45G is a direct transcriptional target of ASCL1
  • PAX5 was found to be an epigenetically inactivated tumour suppressor that inhibits non-small cell lung cancer (NSCLC) proliferation and metastasis, through down-regulating the CTNNB1 pathway and up-regulating GADD45G expression
  • GADD45A and GADD45G, directly interact with CDK11A and thereby inhibit CDK11A activity, and consequentially SPDEF phosphorylation and degradation, ultimately reducing prostate cancer cell migration and invasion
  • GADD45 proteins bind the JNK kinase mitogen-activated protein kinase kinase 7 (MAP2K7) and inhibit its activity, even under normal physiological conditions
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    of GADD45G-ZEB2 axis may contribute to cellular senescence evasion and hepatocellular carcinoma (HCC) development
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • is a candidate gene for male infertility and 46,XY sex reversal in humans
  • Marker
  • GADD45G suppression is a poor prognostic factor in patients with hepatocellular carcinoma (HCC)
  • Therapy target
    ANIMAL & CELL MODELS
  • Gadd45g(-/-) XY mice were born as completely sex-reversed XY-females, whereas lack of Gadd45a and/or Gadd45b did not affect primary sex determination or testis development