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FLASH GENE
Symbol EHF contributors: mct/npt - updated : 03-09-2013
HGNC name ets homologous factor
HGNC id 3246
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal A domain, involved in transactivation
  • a central AT hook domain
  • C terminal ETS DNA binding domain
  • HOMOLOGY
    interspecies ortholog to murine Ehf
    intraspecies homolog to ETS factor
    Homologene
    FAMILY
  • ETS transcription regulator family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting as a transcriptional repressor
  • involved in epithelial differentiation and carcinogenesis
  • playing a role in the induction of cellular senescence as a downstream molecule of MAPK14
  • regulates TNFRSF10B expression through Ets binding sequences on the TNFRSF10B promoter
  • ELF3 and EHF play an important role in airway inflammation
  • controls prostate epithelial cell differentiation and stem-like potential
  • key role for EHF in the development of a subset of prostate tumors
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development , mitochondrial transport
    text transcriptional repressor
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • directly activates the transcription of RUVBL1, an ATPase associated with chromatin-remodelling complexe
  • DCDC2 is a novel ESE3/EHF oncogenic target in prostate cancer
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in prostate cancer, silenced by methylation of an evolutionarily conserved CpG site in its promoter
    Susceptibility to asthma
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    EHF and RUVBL1 might be promising molecular targets for the treatment of colon tumours
    ANIMAL & CELL MODELS