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FLASH GENE
Symbol GMEB2 contributors: - updated : 10-09-2005
HGNC name glucocorticoid modulatory element binding protein 2
HGNC id 4371
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal KDWK domain, necessary for DNA binding
  • a SAND (DNA binding) domain
  • a highly acidic C terminus that likely forms a coiled-coil structure
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus glucocorticoid modulatory element binding protein
    intraspecies homolog to GMEB1
    Homologene
    FAMILY KDWK family of proteins
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • modulator of transactivation by the glucocorticoid receptor, essential for parvovirus DNA replication
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer of GMEB1 and GMEB2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding glucocorticoid receptor modulatory elements
  • may interact with CREB- binding protein (CBP)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS