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FLASH GENE
Symbol GDA contributors: - updated : 04-09-2007
HGNC name guanine deaminase
HGNC id 4212
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • a nine residue N terminal motif that is present in other aminohydrolases and amidohydrolases
  • zinc binding, collapsin response mediator protein (CRMP) homology domain
  • PSD-95, Discs large, zona occludens-1 binding domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to Drosophila CG18143
    homolog to C.elegans T20D4.9
    homolog to rattus guanine aminohydrolase
    homolog to murine Gda guanine deaminase
    intraspecies homolog to CRMP1,weakly
    Homologene
    FAMILY ATZ/TRZ family
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the hydrolytic deamination of guanine
  • producing xanthine and ammonia
  • may have a role in clustering neurotransmitter receptors
  • may influence synaptic development and plasticity by regulating postsynaptic protein sorting
  • regulates dendrite patterning in hippocampal neurons by promoting microtubule assembly
  • decreases PSD-95 family member localization and regulates dendrite number
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text neurogenesis, synaptic development and plasticity
    PATHWAY
    metabolism nucleic , purine/pyrimidine
    signaling
    purine nucleotide catabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+ (one ion per subunit)
    protein
  • regulating DLG4 (PSD-95) postsynaptin targeting
  • binds directly to tubulin heterodimers and promotes microtubule polymerization, via its CRMP homology domain to promote microtubule assembly
  • interacting with SNAPAP (coiled-coil domain (H2) of SNAPAP is required for GDA binding)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS