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FLASH GENE
Symbol ITSN2 contributors: mct - updated : 13-06-2016
HGNC name intersectin 2
HGNC id 6184
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two EH domains
  • a coiled-coil region
  • five SH3 domains of ITSN2 bound well-established interactors of ITSN1 as well as newly identified ITSNs protein partners
  • a EF-hand calcium-binding domain
  • C-terminal extension encoding a Dbl homology domain (DH), a pleckstrin homology domain (PH) and a C2 domain, suggesting that it could act as a guanine nucleotide exchange factor for Rho-like GTPases, with possible roles of C2 domain in regulating the activity of CDC42
  • HOMOLOGY
    Homologene
    FAMILY
  • SH3P18-WASP associated protein
  • member of a family of proteins involved in clathrin-mediated endocytosis
  • CATEGORY adaptor , transport
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • regulating the formation of clathrin-coated vesicles
  • functioning in the induction of T cell antigen receptor (TCR)
  • SH3/SH2 adaptor protein
  • ITSN1 and ITSN2 are conserved proteins involved in clathrin-mediated endocytosis
  • guanine nucleotide exchange factor for CDC42, regulating different steps of caveola endocytosis in Endothelial cells by controlling the temporal and spatial actin polymerization and remodeling sub-adjacent to the plasma membrane
  • multimodule scaffolding protein functioning in membrane-associated molecular trafficking and signal transduction pathways
  • ITSN1 and ITSN2, are crucial for the initiation stage of clathrin-mediated endocytosis
  • during evolution of vertebrates ITSN2 acquired a novel protein-interaction interface that allows its specific recognition by the SH2 domains of signaling proteins
  • ITSN1, ITSN2 are scaffold proteins involved in the molecular mechanisms of invadopodia formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport
    PATHWAY
    metabolism
    signaling
    a component
  • belong to a complex containing multimers of ITSN1, ITSN2 and EPS15 and differents partners
  • ITSN1, ITSN2 form homomeric and heteromeric complexes with each other revealing an added level of complexity in the function of these evolutionarily conserved scaffolds
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • bindind to EPS15
  • binding factor of EPS8, and ITSN2 interacts with EPS8 and stimulates the degradation of EPS8 proteins
  • ITSN2 is a major transducer of ING1a-induced senescence signaling
  • WIPF1 interacts with endocytic adaptor proteins of the intersectin (ITSN) family, ITSN1 and ITSN2
  • WIPF3 acts as a modulator of ITSN1, ITSN2 scaffold proteins association with actin
  • ITSN1 and ITSN2 are podocytic guanine nucleotide exchange factors for CDC42
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS