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FLASH GENE
Symbol NDRG2 contributors: mct/npt/pgu - updated : 21-09-2015
HGNC name NDRG family member 2
HGNC id 14460
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • lacking the hydrophilic sequence of NDRG1
  • a central alpha-beta-hydrolase fold domain
  • several phosphorylation sites (its phosphorylation is mediated through insulin-stimulated AKT activation)
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Ndrg2 (95.5pc)
    homolog to rattus Ndrg2 (95.8pc)
    intraspecies homolog to NDRG1
    homolog to NDRG4 (60p1000)
    Homologene
    FAMILY
  • N-myc downregulated gene (NDRG) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    basic FUNCTION
  • may be playing a role in neurite outgrowth
  • may be a tumor suppressor gene
  • implicated in cell growth, differentiation, and apoptosis and is rapidly responsive to mineral corticoid-stimulation in the kidney
  • inhibiting JAK2 or STAT3 activation in a MAPK14 dependent manner and up-regulating the expression level of SOCS1 mRNA and protein
  • growth inhibitory gene in signal transduction pathway of breast cancer tumor cells
  • may play a partially redundant role in specific cells in the brain
  • possible role for NDRG2 in the intracellular signaling pathway mediated by modulation of the phosphorylation of the C-terminal amino acids
  • might have a pivotal role as one of intrinsic factors for the modulation of MAPK14 phosphorylation, and subsequently involve in controlling of IL10 production
  • candidate tumor-suppressor gene for oral squamous-cell carcinoma (OSCC) development and probably contributes to the tumorigenesis of OSCC partly via the modulation of Akt signaling
  • specifically expressed in dendritic cells (DC) differentiation and might have a biological role as an internal regulator for DC differentiation and function
  • its expression was negatively correlated with malignancy in hepatocellular carcinoma
  • exerted its anti-tumor activity by regulating CD24, a molecule that mediates cell-cell interaction, tumor proliferation and adhesion
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MCRS1
  • NDRG2 is a novel target for TRIM32 and TRIM32 is involved in control of myogenic cells proliferation and differentiation
  • regulation of GRIK2 by SGK1 and NDRG2 in astrocytes may play an important role in gliotransmission, modulation of gene expression and regulation of exocytosis of tissue-type plasminogen activator (tPA)
  • cell & other
    REGULATION
    inhibited by down-regulated by Myc through transcriptional repression on its core promoter region
    Other its expression is regulated by promoter methylation and miR-650 in colorectal cancer cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    by hypermethylation of the promoter in grade III meningioma
    tumoral     --low  
    in liver and pancreatic cancers
    tumoral     --low  
    in glioblastoma, lung and breast cancer, and clinically aggressive meningioma
    constitutional     --over  
    in Alzheimer disease
    tumoral     --over  
    overexpression inhibits glioblastoma (GBM) cell proliferation, and decreased NDRG2 expression correlates with decreased GBM patient survival
    tumoral     --low  
    dependent on promoter methylation, was seen in the majority of oral squamous-cell carcinoma cases and in several cases of precancerous leukoplakia with dysplasia
    tumoral     --low  
    in colorectal cancer compared to benign colorectal tissues, and hypermethylation of NDRG2 was significantly correlated with nodal metastasis and poor differentiation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • biomarker to predict aggressive behavior in patients with meningioma
  • aberrant hypermethylation of the NDRG2 gene could be a molecular marker for detection and treatment of human colorectal cancers
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhead and neck 
    potential target for therapeutic intervention in oral squamous-cell carcinoma
    ANIMAL & CELL MODELS
    Tbx2 in the embryonic mouse heart at early stages of development throughout the myocardium of the heart tube both represses proliferation and impairs secondary heart field (SHF) progenitor cell deployment into the outflow tract (OFT), implicating the upregulation of Ndrg2 and downregulation of Ndrg4 expression