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FLASH GENE
Symbol DPT contributors: mct - updated : 02-11-2016
HGNC name dermatopontin
HGNC id 3011
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • a binding site in DPT for FN1 was identified as the DPT-4 (PHGQVVVAVRS) peptide
    • HOMOLOGY
    Homologene
    FAMILY dermatopontin family.
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    text
  • located mainly in the cytoplasm of several cell types in the liver, and also in the extracellular matrix of the skin
    • basic FUNCTION
  • may be mediating adhesion by cell surface integrin binding
  • promoting cell adhesion and cytoplasmic spreading of dermal fibroblasts and accelerating the assembly of collagen into fibrils
  • may be one of the regulators used to remodel the uterine extracellular matrix for pregnancy
  • can play various roles in different tissues and might be a molecule related to carcinogenesis and the progression of hepatocellular carcinoma via possible interaction with TGF-beta1 and other potential mechanisms
  • promotes fibronectin fibril formation probably by changing the fibronectin conformation
  • has an accelerating role in fibroblast cell adhesion to the provisional matrix in the initial stage of wound healing
  • first non-integrin protein that can activate Fibronectin (FN) and induce FN fibril formation, and in a context of FN activation, may help a wound to heal by accumulating in the wound either from the surrounding ECM or from the serum
  • acidic extracellular matrix (ECM) protein that plays a critical role in both ECM structure and wound healing
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • proteoglycan binding
  • binding to decorin
  • downstream target of vitamin D receptor
  • promotes strong epidermal cell adhesion via alpha3beta1 integrin and syndecan
  • interacted with Fibronectin (FN) and fibrin and enhanced the cell adhesion activity of FN
  • a binding site in DPT for FN1 was identified as the DPT-4 (PHGQVVVAVRS) peptide, and the major binding site in FN1 for DPT was the 14th type III repeat (III14) domain
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in uterine leiomyoma and keloids
    tumoral     --low  
    in hepatocellular carcinoma
    constitutional germinal mutation      
    in autosomal dominant (AD) familial Meniere disease (FMD)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Dpt-kockout mice exhibit an Ehlers-Danlos syndrome phenotype