basic FUNCTION
| potentiate nuclear receptor activity |
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plays a role in the regulation of certain endogenous RARalpha target genes and that RQCD1 and might mediate their function through their interaction with ZNF335 |
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play a role in cell survival, in contrast to the CNOT7 and CNOT8 deadenylase subunits of CCR4-NOT complex |
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key regulator of insulin-like growth factor-binding protein 5, which mediates cell cycle arrest and senescence via a TP53-dependent pathway |
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CNOT7/8 catalytic subunits are essential for deadenylation, which is necessary to maintain cell viability, whereas CNOT6/6L are not |