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FLASH GENE
Symbol CNOT6 contributors: mct - updated : 25-10-2015
HGNC name CCR4-NOT transcription complex, subunit 6
HGNC id 14099
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal nuclease domain with homology to the endonuclease-exonuclease-phosphatase (EEP) family of enzymes
  • HOMOLOGY
    interspecies homolog to yeast glucose repressible alcohol dehydrogenase transcriptional effector
    intraspecies homolog to CNOT6L
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • potentiate nuclear receptor activity
  • plays a role in the regulation of certain endogenous RARalpha target genes and that RQCD1 and might mediate their function through their interaction with ZNF335
  • play a role in cell survival, in contrast to the CNOT7 and CNOT8 deadenylase subunits of CCR4-NOT complex
  • key regulator of insulin-like growth factor-binding protein 5, which mediates cell cycle arrest and senescence via a TP53-dependent pathway
  • CNOT7/8 catalytic subunits are essential for deadenylation, which is necessary to maintain cell viability, whereas CNOT6/6L are not
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • targets DNA-damage response proteins
  • CNOT7, CNOT8 cooperate with CNOT6, CNOT6L in mRNA deadenylation, suggesting that the enzyme activities of CNOT7, CNOT8 and CNOT6, CNOT6L are regulated via allosteric interactions within the nuclease module
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS