Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PIP5K1A contributors: mct/npt - updated : 16-04-2014
HGNC name phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
HGNC id 8994
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer complex
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
text plasma membrane-associated protein
basic FUNCTION
  • phosphatidylinositol-4-phosphate-5 kinase, type 1 alpha, putatively involved in membrane ruffle formation
  • playing a role in regulating stress-induced apoptosis
  • activation of KIF2A is not sufficient but is essential for the function of PIP5K1A
  • PIP5K1A and PIP5K1B may coordinately and/or redundantly function in the maintenance of sperm number and morphology during spermatogenesis
  • cytosolic PIP5K1A has been implicated in several cellular events like endocytosis, membrane ruffling and migration; the nuclear pool has been shown to be involved in pre-mRNA splicing events
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PIPSL is the fusion of phosphatidylinositol-4-phosphate 5-kinase (PIP5K1A) and 26S proteasome subunit (S5a/PSMD4) genes
  • suppressed the elongation of axon branches in a KIF2A-dependent manner, suggesting a unique PIPK-mediated mechanism controlling MT dynamics in neuronal development
  • cell & other
    REGULATION
    activated by the small G protein ADP-ribosylation factor ARF6
    Other nuclear PIP5K1A is modified by SUMO1 in normal cells
    modified by polySUMO-2 only during apoptosis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene potentialy target for the treatment of prostate cancer
    Marker
    Therapy target
    ANIMAL & CELL MODELS