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FLASH GENE
Symbol MSLN contributors: shn/npt - updated : 09-02-2013
HGNC name mesothelin
HGNC id 7371
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal 33-AA signal sequence, and a region (296-359) consisting of 64 AAs at the N-terminal of cell surface mesothelin as the minimum fragment for complete binding activity to MUC16
  • four potential N-glycosylation sites
  • a MUC16-binding domain, significantly inhibiting cancer cell adhesion
  • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies ortholog to Msln, Rattus norvegicus
    ortholog to Msln, Mus musculus
    ortholog to MSLN, Pan troglodytes
    Homologene
    FAMILY
  • mesothelin family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • megakaryocyte potentiating factor
  • putatively involved in cell adhesion
  • enables cells to survive under anchorage-independent conditions by suppressing BCL2L11 induction via the extracellular signal-regulated kinase signaling pathway
  • cell surface glycoprotein that is overexpressed in human pancreatic cancer
  • activate PI3K (phosphoinositide 3-kinase)/Akt signalling and inhibit paclitaxel-induced apoptosis
  • MUC16 and mesothelin (MSLN), are associated with the invasion process in patients with pancreatic ductal adenocarcinoma
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between mesothelin (MSLN) and MUC16 may facilitate the implantation and peritoneal spread of tumors by cell adhesion
  • enhances ovarian cancer invasion by MMP7 expression through the MAPK/ERK and JNK signal transduction pathways
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    only in ovarian carcinoma and mesotheliomas
    tumoral     --over  
    promotes breast cancer cell invasiveness and metastasis
    tumoral     --over  
    by hypomethylation in malignant mesothelioma
    tumoral     --over  
    in human pancreatic cancer, leading to constitutive activation of STAT3, which results in enhanced expression of cyclin E and cyclin E/cyclin-dependent kinase 2 complex formation as well as increased G(1)-S transition
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker useful biomarker for breast cancer progression
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    potential new therapeutic agent for preventing or treating peritoneal malignant tumors
    cancerreproductivebreast
    novel therapeutic or chemopreventive target in human breast cancer
    ANIMAL & CELL MODELS
    mice disrupted for msln gen were viable, fertile and anatomically normal