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FLASH GENE
Symbol GSPT2 contributors: mct - updated : 24-11-2015
HGNC name G1 to S phase transition 2
HGNC id 4622
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an elongation factor Tu domain
  • HOMOLOGY
    interspecies ortholog to murine Gspt2
    homolog to Drosophila Elf
    homolog to C.elegans H19N07.1
    intraspecies homolog to GSPT1
    Homologene
    FAMILY
  • GTP-binding elongation factor family
  • ERF3 subfamily
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • translation elongation factor
  • GSPT1 is the major factor acting in translation termination in mammals and GSPT2 can substitute for GSPT1 in this function
  • GSPT2 originated through retrotransposition of processed GSPT1 transcript into the genome
  • CELLULAR PROCESS cell cycle, checkpoint
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule nucleotide,
  • GTP
  • protein
  • ETF1
  • GSPT2 overexpression alleviated the effect of GSPT1 silencing on readthrough and on ETF1 cellular levels
  • interaction between BIRC5 and GSPT1, GSPT2
  • biomarker for hepatocellular carcinoma, influencing cell cycle and phosphoralation status of EIF4EBP1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by promoter methylation in colorectal cancer patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS