basic FUNCTION
| single stranded DNA-stimulated ATPase and ATP-dependent DNA helicase |
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may play an important role in insulin-stimulated SLC2A4 translocation through its interaction with TBC1D4 |
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regulates telomerase at two different levels |
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essential eukaryotic AAA+ ATPase involved in a variety of cellular processes, such as chromatin remodeling during double-strand break repair, transcriptional regulation, control of cell proliferation and small nucleolar RNA biogenesis |
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chromatin-remodeling factor, methylated at lysine 67 in hypoxic conditions by the methyltransferase EHMT2 |
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may also function as a novel modulator of apoptosis pathway with PIH1D1 |
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implicated in ETS2 mediated regulation of TERT in colon cancer which has functional and clinical consequences |
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RUVBL1/RUVBL2 complex regulates PIKK-mediated stress responses through physical interactions with PIKKs (phosphatidylinositol 3-kinase-related protein kinase) and by controlling PIKK mRNA levelsv |
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RUVBL1 and RUVBL2, also known as Pontin and Reptin, are AAA+ proteins essential in small nucleolar ribonucloprotein biogenesis, chromatin remodelling, nonsense-mediated messenger RNA decay and telomerase assembly |
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RUVBL1, RUVBL2 act as molecular adaptors that can substitute for one another to facilitate the optimal assembly, heat stability, and function of the TIP60 complex |
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RUVBL1, RUVBL2 are required for efficient transcription of type I interferon-stimulated genes |