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FLASH GENE
Symbol POLK contributors: - updated : 27-09-2004
HGNC name polymerase (DNA directed) kappa
HGNC id 9183
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • from the N terminus,five highly conserved motifs, I, II, III likely involved in DNA binding and nucleotidyltransferase activities, IV and V representing the helix-hairpin-helix motif
  • two zinc finger domains of C2H2 type in the C terminal region
  • HOMOLOGY
    interspecies homolog to E.coli Din B
    intraspecies homolog to RAD30 related
    Homologene
    FAMILY member of the UmuC/DinB superfamily of by pass DNA polymerase
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • DNA polymerase IV, facilitating the replication of templates containing abnormal bases of possessing structurally aberrant replication forks inhibitinh normal DNA synthesis
  • unable to by pass a TT dimer non abasic site
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS