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FLASH GENE
Symbol NINL contributors: mct/npt/pgu - updated : 04-09-2008
HGNC name ninein-like
HGNC id 29163
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three EF-hand domains
  • four coiled-coil domains
  • specific phosphorylation sites are mapped at Ser-185, Ser-448, and Ser-585
    • HOMOLOGY
    interspecies homolog to mus ninein
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • found to localize at midbody during cytokinesis
    • basic FUNCTION
  • centrosome protein involved in microtubule nucleation, and in microtubule organisation in interphase cells
  • may play a role in ovarian carcinogenesis
  • contributes to chromosome segregation and cytokinesis
  • BRCA1-associated centrosomal protein that is required for centrosomes maturation at interphase and spindle formation in mitosis, also contributes to the accomplishment of cytokinesis
  • modulation of NINL by Aurora B might be vital to the commitment of cytokinesis and maintenance of genomic stability
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with LCA5 and USH2A isoform b
  • can be recruited by Aurora B to the midbody apparatus via their physical association at the late stage of mitosis
    • cell & other
    REGULATION
    Other expression cell cycle-dependent and regulated by APC-mediated protein degradation
    regulated by Aurora B is critical for the completion of cytokinesis, providing novel insights into understanding the machinery of cell cycle progression
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian cancer overexpression was marginally associated with decreased overall survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate gene for USH, LCA and allied retinal ciliopathies
    Marker
    Therapy target
    ANIMAL & CELL MODELS