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FLASH GENE
Symbol POFUT2 contributors: mct - updated : 15-02-2012
HGNC name protein O-fucosyltransferase 2
HGNC id 14683
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to C-elegans Pad-2
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,organelle,Golgi
text colocalizing with giantin, a Golgi-specific protein
basic FUNCTION
  • playing a potential role in Down syndrome phenotype
  • O-fucosylate Thrombospondin type 1 repeats (TSRs) but not EGF-like repeats
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS