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FLASH GENE
Symbol MYRF contributors: mct/npt - updated : 26-03-2014
HGNC name myelin regulatory factor
HGNC id 1181
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two transmembrane helices
  • two proline-rich region
  • a MYRF domain indeed serves as an intramolecular chaperone that facilitates MYRF trimerization and proteolysis
  • HOMOLOGY
    interspecies homolog to C.Elegans F21A10.2
    intraspecies homolog to protein Best's macular dystrophy
    Homologene
    FAMILY
  • MRF family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • playing a necessary role for the generation of mature myelin-gene-expressing oligodendrocytes within the CNS (Emery 2009)
  • transcriptional regulator vital for the generation of myelinating oligodendrocytes, with an analogous role in the CNS to that of EGR2 in the PNS (Emery 2009)
  • is required for the generation of CNS myelination during development and also for its maintenance in the adult
  • is a novel example of a membrane-associated transcription factor and provide a direct molecular mechanism for its regulation of oligodendrocyte differentiation and CNS myelination
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is an oligodendrocyte-specific target of SOX10 (MYRF cooperates with SOX10 to implement the myelination program as evident from the physical interaction between both proteins and the synergistic activation of several myelin-specific genes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS