basic FUNCTION
| nuclear Cdc2-related kinase, prototype for a new group of MAPK-like kinases requiring dual phosphorylation at TDY motifs |
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MAK and ICK require dual phosphorylation in a TDY motif catalyzed by an unidentified human threonine kinase and tyrosine autophosphorylation |
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may play a role in cardiac development |
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playing an important role in intestinal epithelial cell proliferation and differentiation |
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plays a key role in the development of multiple organ systems |
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highly conserved serine/threonine protein kinase, that supports cell proliferation and G(1) cell cycle progression |
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important role for ICK in modulating the activity of MTOR through phosphorylation of Raptor Thr-908, implicating a potential signaling mechanism by which ICK regulates cell proliferation and division |