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FLASH GENE
Symbol ICK contributors: mct/npt/pgu - updated : 15-05-2013
HGNC name intestinal cell (MAK-like) kinase
HGNC id 21219
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal catalytic domains, related to mitogen-activated protein kinases (MAPKs) and containing a corresponding TDY motif
  • a dual phosphorylation site found in mitogen-activating protein (MAP) kinases
  • C-terminal noncatalytic domains
  • HOMOLOGY
    interspecies homolog to rattus S/T-protein kinase
    Homologene
    FAMILY
  • Ser/Thr protein kinase family
  • CDK subfamily
  • CATEGORY enzyme , receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • nuclear Cdc2-related kinase, prototype for a new group of MAPK-like kinases requiring dual phosphorylation at TDY motifs
  • MAK and ICK require dual phosphorylation in a TDY motif catalyzed by an unidentified human threonine kinase and tyrosine autophosphorylation
  • may play a role in cardiac development
  • playing an important role in intestinal epithelial cell proliferation and differentiation
  • plays a key role in the development of multiple organ systems
  • highly conserved serine/threonine protein kinase, that supports cell proliferation and G(1) cell cycle progression
  • important role for ICK in modulating the activity of MTOR through phosphorylation of Raptor Thr-908, implicating a potential signaling mechanism by which ICK regulates cell proliferation and division
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • Mg2+
  • protein
  • Scythe is a physiological substrate for ICK
  • interacts with the MTOR/Raptor complex in cells, and is able to phosphorylate Raptor Thr-908
  • cell & other
    REGULATION
    activated by dual phophorylation of the TDY motif (Y-159 and T-157), such that it autophosphorylates at Y-159
    ASSOCIATED DISORDERS
    corresponding disease(s) ECO
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS