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FLASH GENE
Symbol ZNF652 contributors: mct/npt - updated : 11-04-2012
HGNC name zinc finger protein 652
HGNC id 29147
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • zinc finger motif
  • HOMOLOGY
    interspecies homolog to rattus zinc finger protein Rkr2
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • CBFA2T3-ZNF652-mediated HEB regulation may play an important role in hematopoiesis and myogenesis
  • CBFA2T3-ZNF652 corepressor complex regulates transcription of the E-box gene TCF12
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complex CBFA2T3-ZNF652
  • INTERACTION
    DNA DNA binding motif
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with CBFA2T3, to repress TCF12 expression, and in addition CBFA2T3 interacts with the TCF12 protein to inhibit its activator function
  • interacts with the ETO protein CBFA2T3 and has a role in the suppression of breast oncogenesis
  • strongly interacts with CBFA2T3 and this interaction occurs through the C-terminal 109 amino acids of ZNF652
  • specifically and functionally interacts with CBFA2T3 to repress transcription of genes involved in breast oncogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    of both AR and ZNF652 in clinically organ-defined prostate cancer are associated with a statistically increased risk of relapse
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS