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FLASH GENE
Symbol PLXND1 contributors: mct/npt - updated : 28-11-2018
HGNC name plexin D1
HGNC id 9107
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal SEMA homology domain
  • two typical and atypical cysteine rich domains sharing homology with the scatter factor reception (MET family) MRS
  • a single transmembrane segment (1TM)
  • a sorting motif that interacts with the adaptor protein GIPC1 to facilitate transport to recycling endosomes
  • HOMOLOGY
    Homologene
    FAMILY
  • calcium-dependent cell adhesion molecule family
  • plexin family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • receptors for multiple (and perhaps all) classes of semaphorins, either alone or in combination with neuropilins, and trigger a novel signal transduction pathway controlling cell repulsion (Tamagnone 1999)
  • its expression during tumor development is strongly correlated with both invasive behavior and metastasis (Roodink 2008)
  • important role in directing migration of maturing thymocytes via modulation of biological responses to chemokine gradients (Choi 2008)
  • novel role of SEMA3E-PLXND1 function in modulating angiogenesis via a VEGFA-induced feedback mechanism (pMID: 21724832)
  • potential role of PLXND1 in cervical cancer-associated angiogenesis
  • PLXND1 operates in a cell context-specific fashion, mediating different synaptogenic outcomes depending upon neuron type
  • PLXND1 is a pivotal mediator of this signaling axis downstream of NOTCH in prostate cancer cells
  • PLXND1 signaling controls likely filopodium-like lateral protrusion (FLP) formation and the termination of neuronal migration through a precise control of microtubule dynamics.
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for the semaphorin 7A (SEMA7A)
  • semaphorin 3E (Sema3E), one of the ligands for PLXND1, has previously been correlated with invasive behavior and metastasis, suggesting that the PLXND1-SEMA3E interaction may play a role in tumor progression (Roodink 2008)
  • receptor of SEMA3E (interacting during the formation of proprioceptive sensory–motor reflex circuits) (Pecho-Vrieseling 2009)
  • SH3BP1 mediates SEMA3E-induced cell collapse through interaction with PLXND1 and regulation RAC1 activity
  • SEMA3E/PLXND1 modulates Immunological synapse (IS) formation and Ag-scanning activities of thymocytes within thymic tissues
  • mesenchymal SEMA3D guides outgrowth of the common cardinal vein via repulsion and signals through PLXND1
  • SEMA3G induces cell collapse in an NRP2/PLXND1-dependent manner
  • GIPC1-mediated endocytic trafficking regulates PLXND1 signaling, and PLXND1 binding to GIPC1 releases the autoinhibition, promoting its interaction with myosin VI
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in metastatic melanomas (Roodink 2008)
    tumoral       gain of function
    in melanoma, breast, colon, ovarian and prostate cancers
    constitutional germinal mutation      
    in PLXND1 and REV3L that are responsible for a proportion of Möbius syndrome (MBS) patients suggesting that de novo mutations in other genes might account for other MBS patients
    constitutional germinal mutation      
    in isolated truncus arteriosus
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • might be a potential cervical cancer biomarker
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    NOTCH1-PLXND1 signaling axis may be targeted to impair prostate cancer cell invasiveness and metastasis
    ANIMAL & CELL MODELS
  • PlxnD1(-/-) mice exhibited defective germinal center (GC) reactions during T-dependent immune activation