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FLASH GENE
Symbol PLXNC1 contributors: mct/npt - updated : 16-03-2010
HGNC name plexin C1
HGNC id 9106
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal SEMA homology domain
  • two cysteine rich domains sharing homology with the scatter factor reception (MET family) MRS
  • a single transmembrane segment (1TM)
  • HOMOLOGY
    Homologene
    FAMILY
  • calcium-dependent cell adhesion molecule family
  • plexin family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • virus-encoded receptor for the semaphorin 7A (SEMA7A)
  • may be involved in the regulation of leukocyte movement
  • potential tumor suppressor protein in melanoma progression, and loss of Plexin C1 expression may promote melanoma invasion and metastasis through loss of inhibitory signaling on cofilin activation (Scott 2009)
  • involved in neural and vascular patterning
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for SEMA7A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in metastatic melanoma compared with primary melanoma (possibility that the Plexin C1 receptor is a tumor suppressor protein for melanoma) (Lazova 2009)
    constitutional     --over  
    in proliferating hemangiomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS