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FLASH GENE
Symbol LANCL1 contributors: mct - updated : 28-03-2009
HGNC name LanC lantibiotic synthetase component C-like 1 (bacterial)
HGNC id 6508
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • seven transmembrane segments
  • seven highly conserved hydrophobic repeats
  • HOMOLOGY
    interspecies homolog to rattus Lancl1 (91.5 pc)
    homolog to murine Lancl1 (91.5 pc)
    homolog to a prokaryotic enzyme responsible for the synthesis of thioether (lanthionine) cross-linking within nascent polypeptide chains, yielding macrocyclic proteins with potent microbicidal activity (Chung 2007)
    Homologene
    FAMILY
  • G protein coupled receptor family
  • LanC-like protein family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in the biosynthesis of antimicrobial peptides
  • glutathione binding protein possibly significant to neurodegenerative disease (Chung 2007)
  • may play a similar role as a peptide-modifying enzyme component in eukaryotic cells (Bauer 2000)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • G-protein coupled receptor protein signaling pathway
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the C-terminal of STOM
  • binding to low-density lipoprotein receptor
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • SOD1G93A transgenic mice, a model for amyotrophic lateral sclerosis (ALS), wherein LanCL1 expression was found to be increased at presymptomatic stages of the disease (Chung 2007)
  • LANCL1 expression in rat testes was initiated already in pachytene spermatocytes in stage IX, but otherwise similar to mouse (Nielsen 2003)