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FLASH GENE
Symbol EIF2B5 contributors: mct - updated : 13-10-2010
HGNC name eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
HGNC id 3261
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a non-catalytic domain important in the eIF2B complex formation and activity
  • HOMOLOGY
    Homologene
    FAMILY
  • EIF-2B gamma/epsilon subunit family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • catalyzing the exchange of eukaryotic initiation factor 2-bound GDP for GTP
  • playing a role in astrocytes generation
  • plays a crucial role in regulating the rate of protein synthesis
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complex of five different subunits; alpha, beta, gamma, delta and epsilon
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) VWM1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS