motifs/domains
| short intracellular N-terminal tail |
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two transmembrane segments (TM1 and TM2) connected by a large ectodomains supporting agonist/antagonist binding, and the second transmembrane domain of P2RX7 contributes to dilated pore formation |
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a large extracellular loop, with a extracellular region surrounding the N187 glycosylation site that is critical for receptor function |
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C-terminal cytosolic domain, long C-terminal end proposed to be responsible for most of the specific biophysical properties of the P2X7R with numerous functions such as connecting the receptor to structures responsible for the large pore formation |
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a 18-AAs domain rich in cysteines in the juxtamembrane C terminus, conserved in all P2X7R orthologs, critical for the general process of current facilitation , and distal C-terminus important for oligomerization and post-translational modification of the receptor, providing a mechanism by which mutations in the trafficking domain disrupt P2RX7 activity and localization at the plasma membrane |
basic FUNCTION
| playing a role in ATP dependent lysis of macrophages and antigen-presenting cells |
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playing a role in pathogenesis of chromic lymphocytic leukemia |
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mediates the NADH transport into astrocytes |
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implicated in ATP secretion from glial cells during Ca2+ wave propagation |
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ATP-gated calcium-permeable cationic channels structurally unique among the P2X family by their much longer intracellular C-terminal tail |
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display a Ca2+-independent facilitation that is responsible for a reduced activation of the receptor |
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plays crucial roles in immune cells initiating and maintaining the inflammatory process through the release of cytokines from the interleukin-1 family |
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is essential to fundamental aspects of the innate immune response |
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has a major role in the regulation of osteoblast and osteoclast activity and changes in receptor function may therefore affect bone mass |
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its activation-triggered Ca(2+) entry and mitochondrial dysfunction played important roles in the ATP-induced neuronal death |
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P2RX7 is important regulator of pancreatic stem cells proliferation and death |
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mediate an anticancer effect via apoptosis in different types of cancer |
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ATP-gated cation channel that promotes microglia activation and plays a critical role in the pathogenesis of Alzheimer disease |
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P2RX7 activation regulates microglial cell death during oxygen-glucose deprivation |
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play a critical role in regulation of the engulfing activity of resting astrocytes |
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role of P2X7R expressed by resting astrocytes in the innate immune system of the CNS |
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nonselective cation channel that is activated by extracellular ATP and triggers the secretion of several proinflammatory substances, such as IL1B, IL18, TNF, and nitric oxide |
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participates in inflammation and pain mechanisms |
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in neurohypophysial terminals, having a role in arginine-vasopressin secretion |
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mediate resistance to toxin-induced cell lysis |
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activates several intracellular signaling cascades, such as the calmodulin, mitogen-activated protein kinase and phospholipase D pathways |
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activation of P2RX7 could likely play an important role in shaping the inflammatory microenvironment in conditions where DEF103B is highly expressed, such as psoriasis or oral carcinoma |