SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,outer
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytoskeleton,microfilament
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| text
| present in dendrites, dendritic spines, and axonal growth cones |
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localizes to the outer mitochondrial membrane, where it has been shown to play a role in the trafficking of mitochondria to the dendritic spine  |
| basic FUNCTION
| regulator of actin reorganization downstream of RAC |
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required for membrane ruffling |
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a possible involvement in the pathogenesis of neuroblastoma |
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thought to be required for lamellipodium and ruffle formation in cells |
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playing a role with its associated proteins in the mid-piece of maturing sperm |
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required for activity-dependent mitochondrial trafficking to dendritic spines and filopodia |
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role for WASF1 as a critical modulator of the innate immune response to severe bacterial infections |
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WASF1 is a maternal reprogramming factor that also has a necessary role in gene activation in development |
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has unique activities independent of Arp2/3 complex that can govern both the growth rates and architectures of actin filament networks |
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playing a role in mitochondrial movement into dendritic protrusions |
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WAS and WASF1 may both be required to build pseudopods |
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plays a critical role in binding actin to initiate actin polymerization |
