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FLASH GENE
Symbol NUBP1 contributors: mct - updated : 27-04-2011
HGNC name nucleotide binding protein 1 (MinD homolog, E. coli)
HGNC id 8041
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ATP/GTP binding motif A phosphate binding (P loop)
  • NUBP/MPP alpha and beta motifs
  • C-terminal region is important for nuclear transfer
  • HOMOLOGY
    interspecies homolog to E.coli mrp gene MinD-like
    homolog to murine Nubp1
    Homologene
    FAMILY MRP/NBP35 family of ATP-binding proteins
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • playing a vital role in cell function
  • involved in the proper placement of the division septum
  • having ATP activity
  • implicated with KIFC1 in a common regulatory pathway involved in the control of centrosome duplication in mammalian cells
  • specifically involved in the formation of extramitochondrial Fe/S proteins
  • CELLULAR PROCESS cell cycle, division
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complex with NUBP1, suggesting the existence of a heteromeric P-loop NTPase complex that is required for both cytosolic Fe/S protein assembly and cellular iron homeostasis
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
  • NUBP1 and NUBP2 proteins interact with each other and regulate their function
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    associated with an impaired maturation of the cytosolic Fe/S proteins glutamine phosphoribosylpyrophosphate amidotransferase and iron regulatory protein 1 (ACO1), while mitochondrial Fe/S proteins remained intact
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS