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FLASH GENE
Symbol PKP3 contributors: mct - updated : 23-06-2016
HGNC name plakophilin 3
HGNC id 9025
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal head domain
  • a potential coiled-coil forming alpha-helix segment a central domain with ten repeats of the Armadillo motif
  • a C terminal tail domain
  • HOMOLOGY
    interspecies homolog to Drosophila Armadillo segment polarity gene
    intraspecies homolog to PKP1
    homolog to PKP2
    Homologene
    FAMILY
  • Armadillo protein family
  • beta-catenin family
  • CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,desmosome
        intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION
  • mediating protein-protein interactions
  • playing a role in junctional plaques
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the plaque protein of desmosomes of most simple and almost all stratified epithelia with the exception of hepatocytes and hepatocellular carcinoma cell
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding of PKP1/3 to FXR1 was RNA independent, and both PKP3 and FXR1 stabilized PKP2 mRNA
  • juxtamembrane region of DSC2 and PKP2, PKP3 are involved in the desmosomal plaque formation, possibly through the interaction between this region and plakophilins
  • PKP3 increases desmosome assembly, size and stability by increasing expression of DSC2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS