Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ID3 contributors: mct - updated : 03-06-2019
HGNC name inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
HGNC id 5362
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • basic helix-loop-helix (HLH) motif, lacking the DNA binding basic domain
  • conjugated ubiquitinated
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to Drosophila extra-macro-chaete (emc)
    homolog to murine ld-3
    Homologene
    FAMILY helix loop helix family of proteins
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • inhibing transcription factors of the basic helix loop helix family
  • required for neurogenesis and angiogenesis
  • functions by a novel mechanism, independent of cell fate determination, to mediate the decision of neural crest precursors to proliferate or die
  • important signaling molecule in estrogen stimulated vascularization and may serve as a therapeutic target in the prevention and treatment of vasculoproliferative disorders (
  • involved in tumor growth, invasiveness, metastasis, and angiogenesis
  • repressor of BHLH activity
  • ID1 and ID3 negatively regulate the transition from lineage-specified hemogenic cells to committed hematopoietic progenitors during hematopoiesis of both embryonic stem cells and induced pluripotent stem cell
  • has been implicated in a variety of functions, including regulation of cell cycle progression and B-cell differentiation
  • morphologically, ID2/ID3 proteins seem to be involved in the granulopoietic maturation
  • ID2 and ID3 enforce follicular regulatory T (TFR) cell- checkpoints and control the maintenance and homing of Treg cells
  • is involved in regulatory mechanisms in adipose tissue and regulates angiogenesis in many tissues including adipose tissue
  • play likely a potential role in the underlying regulatory mechanisms of metabolic health in human obesity
  • contributes to the acquisition of molecular stem cell-like signature in microvascular endothelial cells
  • ID3 is the BMP2-induced transcriptional regulator, promoting adult neural stem/precursor cells (NSPCs) differentiation into astrocytes upon CNS injury
  • ID3 expression is high in follicular B lineage cells but declines in germinal center (GC) cells
  • during the GC reaction, ID3 levels decline to activate the expression of genes encoding signaling components that mediate B cell receptor- and or cytokine receptor-mediated signaling to promote the differentiation of GC B cells
  • is required for tumor angiogenesis and regulatory T-cell generation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer with other HLH proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FMR1 (RNA target of FMR1)
  • SMURF2 is an E3 ligase that ubiquitinates ID1 and ID3 (SMURF2-mediated ubiquitination and consequent degradation of ID1 or ID3 plays an important role in the regulation of Id expression in senescent cells
  • ANKRD2 and ID3 cooperatively inhibit myoblast differentiation by physical interaction
  • MDC1 interacts with a helix-loop-helix (HLH)-containing protein called inhibitor of DNA-binding 3 (ID3)
  • cell & other
    REGULATION
    repressed by ZBTB18, repressing ID1, ID2, ID3, ID4 genes during corticogenesis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    neuroblastoma, ovarian adenocarcinoma
    tumoral     --over  
    in Burkitt lymphoma
    constitutional     --other  
    aberrant expressions of endometrial ID3 and CTLA4 are associated with unexplained repeated implantation failure and recurrent miscarriage
    tumoral     --over  
    was associated with shorter survival of medulloblastoma patients, especially in Group 4 medulloblastomas
    Susceptibility
  • to carotid intima-media thickness
  • to coronary artery pathology
  • Variant & Polymorphism SNP
  • common SNP in the ID3 gene linked to loss of ID3 function and increased carotid intima-media thickness
  • association of ID3 SNP rs11574 directly with human coronary artery pathology
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    peptide aptamer, Id1/3-PA7, specifically interacting with ID1 and ID3, could represent a nontoxic exogenous agent that can significantly provoke antiproliferative and apoptotic effects in breast cancer cells, which are associated with deregulated expressi
    ANIMAL & CELL MODELS
  • combined Id1 and Id3 deletion leads to dysregulation of the hematopoietic transcriptional network and multiple defects in erythropoietic development in adult mice