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FLASH GENE
Symbol PKIG contributors: mlc - updated : 14-12-2007
HGNC name protein kinase (cAMP-dependent, catalytic) inhibitor gamma
HGNC id 9019
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal inhibitory region that includes a pseudosubstrate sequence
  • a central region containing a leucine and hydrophobic aminoacid rich nuclear export sequence
  • a non conserved C terminus
  • HOMOLOGY
    Homologene
    FAMILY cAMP-dependent protein kinase (PKA) inhibitor family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • acting as a potent competitive PKA inhibitor
  • extremely potent competitive inhibitor of cAMP-dependent protein kinase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with BMP2 (activation of the PKA pathway may be one of key BMP2-activated signaling events that lead to osteogenesis and downregulation of PKIG may be prerequisite for the PKA activation during the osteoblastic differentiation of precursor cells)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS