Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NUP160 contributors: mct/pgu - updated : 29-05- 201
HGNC name nucleoporin 160kDa
HGNC id 18017
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus
intracellular,nuclear envelope,pore
text close to the nuclear envelope
basic FUNCTION
  • histidine acid phosphatase, binding proteins to the nuclear pore complex
  • NUP107-160 complex is dynamic in mitosis and promotes spindle assembly in a manner that is distinct from its functions at interphase nuclear pores
  • NUP107-160 subcomplex is stable throughout the cell cycle, and phosphorylation does not affect interactions within the NUP107-160 subcomplex, but regulates the association of the subcomplex with the NPC and other proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • NUP107-160 complex interacts with CENPF, but CENPF only moderately contributes to its targeting to kinetochores
  • KPNB1 forms a high-molecular-weight complex with both AHCTF1 and the NUP107-160 complex in cytosol
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NUP107-160 interacts with the gamma-tubulin ring complex (gamma-TuRC), an essential and conserved microtubule nucleator, and recruits gamma-TuRC to unattached kinetochores
  • N terminus of POM121 directly binds the beta-propeller regions of NUP155 and NUP160
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    alterations in specific proteins (NDC1, NUP160, NUP153 and NUP93) in ischaemic and dilated human heart
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS