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FLASH GENE
Symbol RCOR1 contributors: mct/npt/pgu - updated : 15-11-2014
HGNC name REST corepressor 1
HGNC id 17441
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two SANT (SW13/ADA2/NCOR/TFIIIB) domains also found in NCOR and SMRTs corepressors for steroid hormone receptors
  • SANT2 domain interacts with DNA (disruption of the SANT2-DNA interaction diminishes RCOR1-dependent demethylation of nucleosomes by AOF2)
  • HOMOLOGY
    interspecies ortholog to murine Rcor1
    Homologene
    FAMILY
  • CoREST family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • corepressor required for regulation of R1 neural silencing transcription factor
  • key regulator of the heat shock stress response
  • central role to control the actions of many transcriptional factors, in large part, by recruitment and activation of a range of chromatin remodeling enzymes
  • enhancing the interaction of KDM1A with SNAI1 and the stability of the ternary complex
  • RCOR1, RCOR2 have largely independent and previously uncharacterized roles in promoting neural stem cells (NSCs) multilineage potential and modulating early neural fate decisions
  • promotes erythropoiesis by repressing hematopoietic stem cells (HSCs) and/or progenitor genes, as well as the genes and signaling pathways that lead to myeloid cell fate
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with REST in non neuronal cells
  • part of a histone deacetylase complex containing HDAC1, HDAC2, AOF2, ZNF261, ZNF198, KIAA0182 and GTF2I
  • formation of a SNAI1–KDM1A–RCOR1 ternary complex critical for the stability and function of these proteins
  • KDM1A/RCOR1/HDAC complex, playing a role during early embryonic development
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with AOF2, forming an elongated structure with a long stalk connecting the catalytic domain of AOF2 and the RCOR1 SANT2 domain (endows AOF2 with the ability to demethylate nucleosomal substrates and that it protects AOF2 from proteasomal degradation)
  • positively regulates KDM1A function
  • binds directly and noncovalently to SUMO2, but not SUMO1, and bridges binding of the histone demethylase KDM1A to SUMO2
  • binding with the tower domain of KDM1A modulated the amine oxidase structure of KDM1A, and thus enhanced the interaction of KDM1A with SNAI1 (interaction with the KDM1A/RCOR1 complex is critical for the stability and function of SNAI1)
  • KDM1A/RCOR1 histone demethylase complex interacts with BCL11A and is required for full developmental silencing of gamma-globin genes in adult erythroid cells
  • SFMBT1 regulates transcription in somatic cells and during spermatogenesis through the formation of a stable complex with KDM1A and RCOR1
  • whereas RCOR2, like RCOR1, facilitates KDM1A-mediated nucleosomal demethylation, RRCOR3 competitively inhibits this process
  • KDM1A/RCOR1 interacts with extranucleosomal DNA when it productively engages its nucleosome substrate
  • cell & other
    REGULATION
    inhibited by PHF21A (inhibits RCOR1/KDM1A-mediated demethylation and may therefore confer negative regulation)
    Other regulated by sumoylation (modulates the transcriptional repression by RCOR1 and is needed for its full repressive activity)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice deleted for Rcor1 are profoundly anemic and die in late gestation