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FLASH GENE
Symbol MAP4K1 contributors: mct/npt - updated : 27-05-2019
HGNC name mitogen-activated protein kinase kinase kinase kinase 1
HGNC id 6863
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal kinase domain, HPK1-N, comprising the kinase domain, confering progenitor cell survival independent of the growth factor IL3 (Arnold 2007)
  • a C-terminal citron homology (CNH) domain, HPK1-C, suppresses NF-kappaB and sensitizes toward activation-induced cell death by a yet undefined cell death pathway (Brenner 2007)
  • HOMOLOGY
    interspecies homolog to murine Map4k1
    Homologene
    FAMILY
  • protein kinase superfamily
  • STE Ser/Thr protein kinase family
  • STE20 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • activation of JUN kinase in the MEKK/JNK/SAPK signaling pathway
  • protein phosphorylation (serine/threonine kinase) activity
  • stress response
  • essential for NF-kappaB activation in T cells (Brenner 2007)
  • kinase specific for CARD11 and MAP4K1-mediated phosphorylation of CARD11 as an additional regulatory mechanism tuning the NF-KB response upon TCR stimulation (Brenner 2009)
  • regulator of TCR-mediated NF-KB activation and that NF-KB activation via MAP4K1 is dependent on CARD11 (Brenner 2009)
  • may function as a novel tumor suppressor and its loss plays a critical role in pancreatic cancer (Wang 2009)
  • regulates stress responses, proliferation, and apoptosis in hematopoietic cells (Wang 2009)
  • regulates stress responses, proliferation, and apoptosis in hematopoietic cells
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with CARD11 in a TCR stimulation-dependent manner and phosphorylates the linker region of CARD11 (Brenner 2009)
  • CUL7/FBXW8 ubiquitin ligase-mediated MAP4K1 degradation revealed a direct link and novel role of CUL7/FBXW8 ubiquitin ligase in the MAPK pathway, which plays a critical role in cell proliferation and differentiation
  • PDIA6 interacted with MAP4K1 and inhibited its phosphorylation, ultimately inhibiting the JNK/JUN signaling pathway
  • cell & other
    REGULATION
    activated by phosphorylation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS