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FLASH GENE
Symbol INSL6 contributors: mct/ - updated : 11-10-2017
HGNC name insulin-like 6
HGNC id 6089
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domain conserved in all eukaryotes and predicted to consist of 1421 tandem HEAT-like (Huntingtin, Elongation factor 3, A subunit of protein phosphatase 2A, and Tor1) repeats
  • protein matching the classical signature of the insulin superfamily with B and A chain regions
  • a signal peptide, a B chain, a connecting C chain, and an A chain
  • a DNA-binding domain that resembles the alphaCTD domain of bacterial RNA polymerase alpha, and is required to resist replication stress
  • C-terminal domain with a DNA-binding domain and interacts with the BLM complex
  • HOMOLOGY
    interspecies homolog to murine Insl6
    homolog to C.elegans T08G5.3
    ortholog to rattus rat INSL6
    Homologene
    FAMILY
  • insulin family
  • insulin/IGF/relaxin family
  • CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
    text
  • meiotic and postmeiotic germ cells of the testis are the principal sites of expression of INSL6
  • basic FUNCTION
  • having a role in sperm development and fertilization
  • required for the progression of spermatogenesis
  • confers a new DNA interface for the BLM complex to maintain normal replication
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
  • integral component of the BLM complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physically interacts with the BLM complex through a conserved C-terminal domain, and the stability of Rif1 depends on the presence of the BLM complex
  • INSL6 is a novel CUL4B substrate in male germ cells, evidenced by its direct polyubiquination and degradation by CUL4B E3 ligase
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    majority of the Insl6-deficient males on a hybrid genetic background exhibited impaired fertility, whereas females were fertile