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FLASH GENE
Symbol AKAP9 contributors: mct/pgu - updated : 18-08-2015
HGNC name a kinase (PRKA) anchor protein (yotiao) 9
HGNC id 379
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an amphipathic helix binding domain
  • a LIZ domain
  • two sets of putative RII (regulatory subunit of protein kinase A) binding motif
  • two KCNQ1 binding domains
  • HOMOLOGY
    Homologene
    FAMILY
  • AKAP family
  • CATEGORY chaperone/stress , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    text
  • specifically concentrated at the neuromuscular junction in skeletal muscle
  • localizes both at the Golgi and at the centrosome
  • AKAP9 spans the bridge between centrioles, co-localizing with CROCC and CEP68 in the linker region
  • localization of AKAP9 at the centrosome has been shown to be required for centrosome integrity and centriole duplication
  • basic FUNCTION
  • A kinase PRKA regulatory subunit (RIIA) anchor protein tethering enzymes near their physiological substrate
  • scaffolding at the centrosome and the Golgi apparatus a number of protein kinases such as CSKN1D, CSKN1E, PKN1, PRKAR2A, PRKAR2B,PRKCE and phosphatases such as PPP1CA, PPP2RA, PPP2R1B NMDA receptor GRIN1
  • recruited to the LAF-1 associated molecular complex (ITGAL), critical for polarization and migration of T cells
  • promoting the association of neuronal ITPR1 to the NR1 NMDA receptor GRIN1
  • important players in the nucleation of microtubules at the Golgi apparatus (
  • has a role in cell migration rather than in cell polarisation of the centrosome/Golgi apparatus (
  • key roles in the organization and activation of receptor molecules at the immune synapse during T-cell signaling events
  • facilitates the microtubule polymerization rate in endothelial cells
  • PRKACA and PDE4D anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome
  • acts as a scaffold for factors involved in microtubule nucleation at the centrosome and coordinates the assembly of protein complexes associating with the intercentriolar bridge
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling neurotransmission , signal transduction
    a component
  • complexing with kendrin (PCNT) and associating with TUBG1 and TUBG2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to a leucine zipper motif of KCNQ1 (for sympathetic nervous system (SNS) regulation of cardiac action potential duration (APD), mediated by alpha-adrenergic receptor activation)
  • binding and potentially involved in cytoskeletal attachment of NMDA receptor GRIN1
  • attaching protein type I protein phosphatase and cAMP dependent PRKA to the NMDA receptor GRIN1
  • TSNAX
  • binding to CIP4 (TRIP10) and to FNBP1, influencing the maintenance of Golgi apparatus
  • binding to ion channel CLIC1 at the Golgi apparatus
  • responsible for the sequestration of TACC4 at centrosome during interphase
  • interacting with GOLGA2 (recruitment of AKAP9 on the Golgi membranes through GOLGA2 allows centrosome-associated nucleating activity to extend to the Golgi, to control the assembly of subsets of microtubules ensuring specific functions within the Golgi or for transporting specific cargos to the cell periphery) (
  • microtubule dependent association of AKAP9 and CCAR1 with RNA stress granules
  • CEP72 is essential for the localization of AKAP9 and KIZ
  • interaction with RAPGEF3 (required for RAPGEF3-stimulated microtubule growth)
  • GOLGA2 binding to the A-kinase anchoring protein AKAP9 participates in the regulation of microtubule nucleation on cis-Golgi membranes
  • CEP68 interacts with the distal C-terminal AKAP9 region
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LQT11
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    AKAP9-BRAF fusion promoting MAPK pathway activation in radiation induced thyroid cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS